The volume represents the proceedings of the 22nd International Conference on Operator Theory, held in Timişoara, Romania, from July 3 to July 8, 2008. It includes a survey on Carleson measures and composition operators, as well as eighteen papers containing original research on a large variety of topics: single operator theory, Banach algebras, \(C^*\)-algebras, von Neumann algebras, moment problems, differential and integral operators, noncommutative probability, and spectral theory.